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Acute Kidney Failure Therapy
Researchers from Seoul National University, Research Institute of Pharmaceutical Sciences describe findings in acute kidney failure therapy
June 26th, 2007
Fresh data on acute kidney failure are presented in the report "Effects of acute renal failure on the pharmacokinetics of telithromycin in rats: negligible effects of increase in CYP3A1 on the metabolism of telithromycin. It was reported that the expression of CYP3A1 increased in rats with acute renal failure induced by uranyl nitrate (rat model of U-ARF) compared with controls. It was shown that telithromycin was mainly metabolized via CYP3A1/2 in rats in this study," researchers in Seoul, Korea report. "Hence, the pharmacokinetic parameters of telithromycin were compared after both intravenous and oral administration at a dose of 50 mg/kg to control rats and a rat...
Source: Drug Law Weekly (2007-06-26)
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