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Drug Law Weekly

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Agranulocytosis Therapy



Findings from Toho University advance knowledge in agranulocytosis therapy



June 26th, 2007

New investigation results, "The relation of initial methimazole dose to the incidence of methimazole-induced agranulocytosis in patients with Graves' disease," are detailed in a study published in Endocrine Journal. According to a study from Tokyo, Japan, "The relation between the incidence of methimazole (methylmercaptoimidazole; MMI)-induced agranulocytosis and initial MMI dose was evaluated in a group of 514 patients with Graves' disease who were treated between 1995 and 2005. One hundred and forty-six (28.40%) patients had received an initial dose of 30 mg MMI and 277 (53.89%) patients had been treated with 15 mg MMI."

"Nine patients (1.75%) developed...


Source: Drug Law Weekly (2007-06-26)

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