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Gene Therapy

Scientists at Lund University, Wallenberg Neuroscience Center publish research in gene therapy

Published in Drug Law Weekly, July 10th, 2007

A report, "Seizure suppression by GDNF gene therapy in animal models of epilepsy," is newly published data in Molecular Therapy. "Temporal lobe epilepsy patients remain refractory to available anti-epileptic drugs in 30% of cases, indicating a need for novel therapeutic strategies. In this context, glial cell line-derived neurotrophic factor (GDNF) emerges as a possible new agent for epilepsy treatment," scientists in Lund, Sweden report.

"However, a limited number of studies, use of different epilepsy models, and different methods of GDNF delivery preclude understanding of the mechanisms for the seizure-suppressant action of GDNF. Here we show that recombinant...

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