Life Sciences

Studies from State University of New York, Department of Pharmacology in the area of life sciences published

Published in Drug Law Weekly, August 14th, 2007

A new study, "Effect of transjunctional KCl gradients on the spermine inhibition of connexin40 gap junctions," is now available. "Spermine inhibits rat connexin40 (Cx40) gap junctions. Glutamate residues at positions 9 and 13 and a basic amino acid (HKH) motif at positions 15-17 on the amino terminal domain are essential for this inhibitory activity," scientists in the United States report.

"Questions remain as to whether spermine occludes the channel within the ion permeation pathway. To examine this question, cis or trans [KCl] was systematically lowered and the equilibrium dissociation constants (K(d)) and kinetics of unilateral spermine block on wild-type Cx40 gap...

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Source: Drug Law Weekly (2007-08-14)

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