Biochemistry

Research from University of Cincinnati, Center for Environmental Genetics in the area of biochemistry described

Published in Drug Law Weekly, August 14th, 2007

A report, "Interaction between the catalytic and modifier subunits of glutamate-cysteine ligase," is newly published data in Biochemical Pharmacology. "Glutamate-cysteine ligase (GCL) is the rate-limiting enzyme in the glutathione (GSH) biosynthesis pathway. This enzyme is a heterodimer, comprising a catalytic subunit (GCLC) and a regulatory subunit (GCLM)," investigators in the United States report.

"Although GCLC alone can catalyze the formation of l-gamma-glutamyl-l-cysteine, its binding with GCLM enhances the enzyme activity by lowering the K(m) for glutamate and ATP, and increasing the K(i) for GSH inhibition. To characterize the enzyme structure-function...

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Source: Drug Law Weekly (2007-08-14)

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