Cancer

New cancer study results reported from University of California

Published in Drug Law Weekly, August 14th, 2007

According to a study from the United States, "Mammalian hexokinase (HXK) is found at the outer mitochondrial membrane, exposed to mitochondrial oxygen- and nitrogen-radicals. Given the important role of this enzyme in metabolic pathways and diseases, the effect of S-nitrosoglutathione (GSNO) on HXK A structure and activity was studied."

"To focus on the catalytic domain, yeast HXK A was used because it has a significant homology to the mammalian domain that contains both the regulatory and catalytic sites. Biologically relevant [GSNO]/[HXK] caused a significant decrease in V-max with glucose (but not with fructose), along with oxidation of 5 Met and nitration of 4 Tyr....

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Source: Drug Law Weekly (2007-08-14)

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