Candidiasis

New candidiasis study findings recently were reported by N.P. Wiederhold and co-researchers

Published in Drug Law Weekly, August 14th, 2007

"In vitro studies have demonstrated that anidulafungin has greater potency than caspofungin against Candida glabrata. However, data from in vivo studies demonstrating that it has superior efficacy are lacking," scientists writing in the journal Antimicrobial Agents and Chemotherapy report.

"The objective of this study was to compare the activities of anidulafungin and caspofungin against C. glabrata in a murine model of disseminated candidiasis. Two clinical C. glabrata isolates were used, including one with reduced caspofungin susceptibility. MICs were determined by broth microdilution in the presence and absence of sera. For the animal studies, mice were...

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Source: Drug Law Weekly (2007-08-14)

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