HIV/AIDS

Research reports from Baylor College of Medicine, College of Medicine provide new insights into HIV/AIDS

Published in Drug Law Weekly, October 9th, 2007

According to a study from the United States, "Clinical use of human immunodeficiency virus protease inhibitors such as ritonavir may be associated with cardiovascular disease. The objective of this study was to determine the effects and molecular mechanisms of ritonavir on cholesterol efflux from human macrophage-derived foam cells, which is a critical factor of atherogenesis."

"Human THP-1 monocytes and peripheral blood mononuclear cells were preincubated with acetylated low-density lipoprotein and [H-3]cholesterol to form foam cells, which were then treated with apolipoprotein AI for cholesterol efflux assay. A clinically relevant concentration of ritonavir (15 mu...

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Source: Drug Law Weekly (2007-10-09)

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