Pharmacology
Study results from University of Torino in the area of pharmacology published
Published in Drug Law Weekly, November 6th, 2007
New investigation results, 'Expression of CYP3A isoforms and P-glycoprotein in human stomach, jejunum and ileum,' are detailed in a study published in Clinical and Experimental Pharmacology and Physiology. According to a study from Torino, Italy, "1. CYP3A isoforms metabolise a diverse array of clinically important drugs and P-glycoprotein (P-gp), a transmembrane efflux pump, can extrude a wide variety of drugs from the cell."
"It has been suggested that the function of CYP3A4 is complementary to that of P-gp along the gastrointestinal (GI) tract, together forming a coordinated intestinal barrier against xenobiotics. Therefore, the expression of CYP3A4, CYP3A5,...
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Source: Drug Law Weekly (2007-11-06)
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