Cancer Vaccines Therapy
Recent findings from M. Iero and co-authors highlight research in cancer vaccines therapy
Published in Drug Law Weekly, November 20th, 2007
New research, 'Low TCR avidity and lack of tumor cell recognition in CD8(+) T cells primed with the CEA-analogue CAP1-6D peptide,' is the subject of a report. "The use of 'altered peptide ligands' (APL), epitopes designed for exerting increased immunogenicity as compared with native determinants, represents nowadays one of the most utilized strategies for overcoming immune tolerance to self-antigens and boosting anti-tumor T cell-mediated immune responses. However, the actual ability of APL-primed T cells to cross-recognize natural epitopes expressed by tumor cells remains a crucial concern," researchers in Milan, Italy report.
"In the present study, we show that...
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Source: Drug Law Weekly (2007-11-20)
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