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Angiology

Research findings from O. Anozie et al update understanding of angiology

Published in Drug Law Weekly, December 25th, 2007

According to recent research from the United States, "We tested the hypothesis that bradykinin (BK)-induced relaxation of phe-nylephrine (PE) and endothelin-1 (ET-1) contractions can be differentially modulated by reactive oxygen species (ROS). Aortic rings isolated from Sprague-Dawley rats were used for the study."

"The contribution of ROS to PE (1x10(-9)-1x10(-5)mol/L)- and ET-1 (1x10(-10)-1x10(-8)mol/L)-induced contractions and the influence of ROS in BK (1x10(-9)-1x10(-5)mol/L) relaxation of PE (1x10(-7)mol/L) or ET-1 (1x10(-9)mol/L)-induced tension was evaluated in the aorta in the presence or absence of the following antioxidants: catalase (CAT, 300 U/mL),...

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