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Breast Cancer

High-dose chemo and stem cell transplant shows little or no survival benefit for breast cancer

Published in Drug Law Weekly, December 25th, 2007

High-dose chemotherapy and autologous stem cell transplantation, the controversial, arduous, yet once-popular combination treatment that fell out of favor as a therapy for breast cancer, has proven not to be beneficial as an adjuvant therapy for women with node-positive disease, according to an expansive analysis conducted by researchers at The University of Texas M. D. Anderson Cancer Center.

In a review of 15 randomized high-dose chemotherapy studies conducted around the world between 1988 and 2002, the investigators from M. D. Anderson, in collaboration with the European Blood and Marrow Transplant Group, report that while there was a slight benefit on relapse-free...

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