Pharmacodynamics
Research from State University of New York has provided new information about pharmacodynamics
Published in Drug Law Weekly, March 4th, 2008
According to a study from the United States, "A mechanism-based pharmacokinetic-pharmacodynamic (PK/PD) model was developed for recombinant human erythropoietin (rHuEPO) to account for receptor-mediated endocytosis via erythropoietin receptor (EPOR) as a primary mechanism for nonlinear disposition of rHuEPO as well as activation of erythropoietic stimulation. Time profiles of rHuEPO concentrations following a wide range of intravenous (i.v.) doses in rats (10, 100, 450, 1,350, 4,050 IU/kg), monkeys (500, 2,000, 4,000 IU/kg), and man (10, 100, 150, 300, 500 IU/kg) were examined."
"The mean data of reticulocytes, red blood cells (RBC), and hemoglobin for five different...
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Source: Drug Law Weekly (2008-03-04)
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