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Depression

Recent findings from M. Taler and co-authors highlight research in depression

Published in Drug Law Weekly, March 4th, 2008

According to recent research published in the journal European Neuropsychopharmacology, "Antidepressants have an antiproliferative effect in some cell tines. Depression may be associated with activation of some pro-inflammatory cytokines."

"Therefore, we evaluated the ex-vivo immunomodulatory effect of selective serotonin reuptake inhibitors (SSRIs) in TceLLs. We found that the SSRIs, paroxetine and sertraline decreased T-cell viability with IC50 around 10 mc M. The inhibition obtained with exposure to the SSRIs was more pronounced than that achieved with dexamethasone. Moreover, these SSRIs inhibit the secretion of the TH1 factor-tumor necrosis factor(TNF)alpha...

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