Life Sciences
Research from N. Boutahar et al broadens understanding of life sciences
Published in Drug Law Weekly, April 1st, 2008
A new study, 'Timing differences of signaling response in neuron cultures activated by glutamate analogue or free radicals,' is now available. "Oxidative stress and excitotoxicity are both involved in the pathogenesis of neuronal degenerative diseases like ALS. In order to compare their action, some key proteins involved in their respective signaling pathways, particularly ERK and p53, were analyzed in primary cultures of cortical neurons subjected to NMDA or H(2)O(2) treatment," scientists in Saint-Etienne, France report.
"Early ERK activation was detected after NMDA treatment and was maintained during 24 h, but not after H(2)O(2) treatment. Early p53 expression was...
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Source: Drug Law Weekly (2008-04-01)
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