Coagulation
Study results from H.Y. Jo and colleagues update understanding of coagulation
Published in Drug Law Weekly, April 1st, 2008
"A novel inhibitory peptide against blood coagulation factor IXa (FIXa) was isolated from the marine echiuroid worm (Urechis unicinctus, order Urechidae). U. unicinctus anticoagulant peptide (UAP), GELTPESGPDLFVHFLDGNPSYSLYADAVPR (M-w: 3344 Da) potently prolonged the activated partial thromboplastin time (APTT), corresponding to inhibition of an endogenous blood coagulation factor in the intrinsic pathway. In the specific factor inhibitory assay, FIXa activity in normal plasma was significantly (P < 0.05) decreased by addition of UAP in dose-dependant manner GC(50) = 42.6 mu g ml(-1))," scientists in South Korea report.
"Binding affinity assay using a surface plasmon...
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Source: Drug Law Weekly (2008-04-01)
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