Immunization

Scientists at University of Miami, Sylvester Comprehensive Cancer Center describe research in immunization

Published in Drug Law Weekly, May 13th, 2008

Research findings, 'Surmounting tumor-induced immune suppression by frequent vaccination or immunization in the absence of B cells,' are discussed in a new report. "Tumor-induced immune suppression is one of the most difficult obstacles to the success of tumor immunotherapy. Here, we show that established tumors suppress CD8 T cell clonal expansion in vivo, which is normally observed in tumor-free mice upon antigen-specific glycoprotein (gp) 96-chaperone vaccination," investigators in the United States report.

"Suppression of CD8 T-cell expansion by established tumors is independent of tumor-associated expression of the antigen that is recognized by the CD8-T-cell...

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Source: Drug Law Weekly (2008-05-13)

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