Pharmacodynamics
Scientists at Seoul National University, Medical Department publish new data on pharmacodynamics
Published in Drug Law Weekly, May 13th, 2008
"Pharmacokinetic and pharmacodynamic profiles of lorazepam and valproate were analyzed according to uridine 5'-diphosphate-glucuronosyltransferase (UGT)2B7 genotype in 14 healthy subjects with UGT2B15*2/*2 genotype. Systemic clearance of lorazepam (2mg intravenously) and area under the concentration-time curve (AUC) of valproate (600mg once daily for 4 days) were analyzed as pharmacokinetic parameters, and area under the effect-time curve (AUEC) of psychomotor coordination tests (Vienna) was used for pharmacodynamic parameter," researchers in Seoul, South Korea report.
"No significant differences were found in systemic clearances of lorazepam by UGT2B7 genotype. AUCs of...
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Source: Drug Law Weekly (2008-05-13)
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