Life Sciences

Studies from University of Modena have provided new information about life sciences

Published in Drug Law Weekly, July 15th, 2008

"It is recognized that paracetamol undergoes a metabolic transformation to N-arachydonylphenolamine (AM404), a CB1 receptor ligand and anandamide uptake inhibitor. Using hot-plate and paw pressure tests, we decided to establish whether AM404 may act through opioidergic and serotonergic mechanisms," investigators in Modena, Italy report.

"Thus, we pretreated rats with opioid mu(1) (naloxonazine) and kappa (MR2266) or 5-HT1A (NAN-190), 5-HT2 (ketanserin), and 5-HT3 (ondansetron) receptor antagonists. We investigated the possible changes in 5-hydroxyindoleacetic acid/serotonin ratio in the frontal cortex and pons. The antinociceptive effect of AM404 (10 mg/kg,...

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Source: Drug Law Weekly (2008-07-15)

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