Neuroblastoma
Research from J.I. Johnsen and co-researchers in the area of neuroblastoma published
Published in Drug Law Weekly, July 29th, 2008
"Mammalian target of rapamycin (mTOR) has been shown to play an important function in cell proliferation, metabolism and tumorigenesis, and proteins that regulate signaling through mTOR are frequently altered in human cancers. In this study we investigated the phosphorylation status of key proteins in the PI3K/AKT/mTOR pathway and the effects of the mTOR inhibitors rapamycin and CCI-779 on neuroblastoma tumorigenesis," scientists in Stockholm, Sweden report.
"Significant expression of activated AKT and mTOR were detected in all primary neuroblastoma tissue samples investigated, but not in non-malignant adrenal medullas. mTOR inhibitors showed antiproliferative effects...
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Source: Drug Law Weekly (2008-07-29)
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