Pharmacokinetics

Studies from University Medical Center reveal new findings on pharmacokinetics

Published in Drug Law Weekly, July 29th, 2008

A new study, 'Effect of food on the pharmacokinetic behavior of the potent oral taxane BMS-275183,' is now available. According to a study from Amsterdam, Netherlands, "BMS-275183 is a potent oral paclitaxel analogue that previously showed promising activity. The goal of the present trial was to investigate whether food affects the pharmacokinetics of BMS-275183."

"Additionally, we evaluated its pharmacokinetic variability using flat-fixed dosing compared with dosing individualized by body surface area (BSA). The patients were treated with 200 mg of BMS-275183 under fasting condition (A), after a standard low-fat meal (B), or after a high-fat meal (C). The patients were...

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Source: Drug Law Weekly (2008-07-29)

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