Tuberculosis

Researchers at Yeshiva University, Medical Department target tuberculosis

Published in Drug Law Weekly, July 29th, 2008

"The intrinsic resistance of Mycobacterium tuberculosis to the beta-lactam class of antibiotics arises from a chromosomally encoded, extended spectrum, class A beta-lactamase, BlaC," researchers in the United States report.

"Herein, we report the X-ray crystallographic structure of BlaC inhibited with clavulanate at a resolution of 1.7 angstrom with an R-factor value of 0.180 and R-free value of 0.212 for the m/z + 154 clavulanate-derived fragment observed in the active site. Structural evidence reveals the presence of hydrogen bonds to the C1 carbonyl along with a coplanar arrangement of C1, C2, C3, and N4, which favors enolization to generate a trans-alpha,beta-...

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Source: Drug Law Weekly (2008-07-29)

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