Drug Delivery Science and Technology
Studies from B. Bittner and co-authors have provided new information about drug delivery science and technology
Published in Drug Law Weekly, July 29th, 2008
"Segments of rabbit colonic tissue were used to investigate the effect of the surface-active excipient Vitamin E-TPGS oil colonic drug absorption. Transport studies in Ussing chambers revealed a statistically significant increase in apparent permeability (P-app) of the P-glycoprotein substrate colchicine in the presence of Vitamin E-TPGS from 1.8 to 2.6*10(-6) cm/s," scientists writing in the Journal of Drug Delivery Science and Technology report.
"The integrity of colonic tissue in these experiments was preserved as demonstrated by electron microscopy. The free fraction of colchicine was not affected by the presence of the surfactant, indicating that the...
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Source: Drug Law Weekly (2008-07-29)
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