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DNA Research

Kyoto University, Institute for Virus Research publishes research in DNA research

Published in Drug Law Weekly, August 12th, 2008

Researchers detail in 'A potential link between alternative splicing of the NBS1 gene and DNA damage/environmental stress,' new data in dna research. According to recent research from Kyoto, Japan, "NBS1 forms a multimetric complex with MRE11/RAD50, which acts as the sensor of DNA double-strand breaks (DSBs). The mechanisms controlling the expression of NBS1 remain largely unknown."

"Here we show that NBS1 is transcribed as both a wild-type and an alternatively spliced form exhibiting a premature stop codon in an alternative 50-bp exon in intron 2. Although the wild-type transcript predominates in most tissues, the spliced transcript is abundant in resting peripheral...

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