Life Sciences
Investigators at University of California, Department of Chemistry zero in on life sciences
Published in Drug Law Weekly, September 9th, 2008
Fresh data on life sciences are presented in the report 'The chemistry of irreversible capture.' "The specific recognition and binding of biological molecules by antibodies is fundamentally important. Natural antibodies are multivalent, having at least two identical ligand-binding sites; this permits them to bind tightly at cell surfaces, which present multiple copies of their target ligands," scientists in the United States report.
"Antibodies that bind to soluble monovalent ligands, such as most small molecules, do not share this multivalent advantage. Nor do engineered fragments of antibodies, such as single-chain Fv proteins or Fab fragments, which generally possess...
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Source: Drug Law Weekly (2008-09-09)
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