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Multiple Sclerosis Clinical Trial

New findings in multiple sclerosis clinical trial described from Vrije University, Department of Radiology

Published in Drug Law Weekly, September 9th, 2008

Scientists discuss in 'Persistent T1 hypointensity as an MRI marker for treatment efficacy in multiple sclerosis' new findings in multiple sclerosis. "MRI is often used as primary outcome measure in phase II clinical trials in multiple sclerosis (MS). Since persistent T1 hypointense lesions are a surrogate parameter for axonal damage and demyelination, they may serve as a marker for monitoring the efficacy of neuroprotective drugs," researchers in Amsterdam, Netherlands report.

"At present, a power analysis using black hole (BH) evolution as primary outcome measure has not been performed. To assess the feasibility of using BH evolution on serial brain MR images as...

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