HIV/AIDS

Data on HIV/AIDS discussed by Y. Hou and colleagues

Published in Drug Law Weekly, September 30th, 2008

According to recent research from the United States, "Small-molecule inhibitors of HIV integrase (HIV IN) have emerged as a promising new class of antivirals for the treatment of HIV/AIDS. The compounds currently approved or in clinical development specifically target HIV DNA integration and were identified using strand-transfer assays targeting the HIV IN/viral DNA complex."

"The authors have developed a second biochemical assay for identification of HIV integrase inhibitors, targeting the interaction between HIV IN and the cellular cofactor LEDGF/p75. They developed a luminescent proximity assay (AlphaScreen (TM)) designed to measure the association of the...

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Source: Drug Law Weekly (2008-09-30)

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