Life Sciences

Research from Liverpool Hospital, Department of Neurology has provided new data on life sciences

Published in Drug Law Weekly, September 30th, 2008

New research, 'Value of therapeutic drug level monitoring and unbound (free) levels,' is the subject of a report. According to a study from Liverpool, Australia, "Therapeutic drug monitoring (TDM) has declined with newer anti-epileptic drugs (AEDs) having no therapeutic window. Use of unbound (free) fraction has almost completely disappeared."

"The case reported highlights its importance and offers sound reason for its retention. A 66-year-old Caucasian man with known epilepsy was admitted with vomiting, ataxia and nystagmus presumably due to AED toxicity. Medications included valproate (VPA) 1g bd; phenytoin (PHT) 200mg tds; carbamazepine (CBZ) 400mg mane, 200mg midi,...

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Source: Drug Law Weekly (2008-09-30)

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