Ankylosing Spondylitis

Reports outline ankylosing spondylitis study findings from D. Vanderheijde and colleagues

Published in Drug Law Weekly, September 30th, 2008

In this recently published article, scientists in Netherlands conducted a study "To evaluate the long-term safety and efficacy of adalimumab in patients with ankylosing spondylitis (AS) and total spinal ankylosis (TSA). Patients (n = 315) with active AS were randomised in a 2:1 ratio to receive adalimumab 40 mg every other week or placebo for 24 weeks followed by open-label adalimumab for up to 5 years."

"Two-year efficacy and safety data for 11 patients with investigator-defined TSA were evaluated. The primary end point was the ASsessment in AS International Working Group criteria for 20% improvement (ASAS20) at Week 12. On or after Week 12, ASAS20 non-responders...

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Source: Drug Law Weekly (2008-09-30)

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