Physiology
Study results from University of Mississippi Medical Center update understanding of physiology
Published in Drug Law Weekly, October 7th, 2008
Data detailed in 'Intracellular pH regulates superoxide production by the macula densa' have been presented. According to recent research from the United States, "We hypothesized that elevated macula densa intracellular pH (pH(i)) during tubuloglomerular feedback enhances O(2)(-) production from NAD(P)H oxidase. Microdissected thick ascending limbs from rabbits with intact macula densa were cannulated and perfused with physiological saline."
"When luminal NaCl was switched from 10 to 80 mM, O(2)(-) production increased from 0.53 ±0.09 to 2.62 ±0.54 U/min (p <0.01). To determine whether inhibiting the Na/H exchanger blocks O(2)(-) production, we used...
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Source: Drug Law Weekly (2008-10-07)
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