Antibiotics

Study findings from National University broaden understanding of antibiotics

Published in Drug Law Weekly, November 25th, 2008

According to recent research from Singapore, Singapore, "A library of chalcones with basic functionalities were evaluated for antibacterial activity against drug sensitive strains of Staphylococcus aureus and Escherichia coli. The most active compounds were 2-52 and 2-57 (MIC 6.3 mc M S. aureus)."

"These compounds had no activity against E. coli (MIC > 100 mc M). Both compounds were characterized by a ring A that was substituted with 2-hydroxy-4,6-dimethoxy-3-(1-methylpiperidin-4-yl) groups. The phenolic OH and 1-methylpiperidinyl groups were required for activity but the phenolic OH may play a more critical role. While the compounds were comparable to licochalcone A...

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Source: Drug Law Weekly (2008-11-25)

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