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Cytokines

Research results from Taichung Veterans General Hospital update knowledge of cytokines

Published in Drug Law Weekly, December 2nd, 2008

According to a study from Taichung, Taiwan, "Recent studies suggest that several second-generation antihistamines can modulate various inflammatory reactions besides their H-1-receptor antagonism. The antihistamine cetirizine is a racemic mixture of levocetirizine and dextrocetirizine."

"The aim of this study was to investigate the effects of these two antihistamines (cetirizine and levocetirizine) on granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin (IL)-8 secretion in A549 human airway epithelial cells. A549 cells were preincubated with cetirizine (0.1, 1, 2.5, 5, and 10 mc M) or levocetirizine (0.1, 1, 2.5, 5, and 10 mc M) individually for 16...

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