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Acidosis
Research from University of Leicester reveals new findings on acidosis
December 16th, 2008
According to a study from Leicester, the United Kingdom, "Insulin resistance is a major cause of muscle wasting in patients with ESRD. Uremic metabolic acidosis impairs insulin signaling, which normally suppresses proteolysis." "The low pH may inhibit the SNAT2 L-Glutamine (L-Gln) transporter, which controls protein synthesis via amino acid-dependent insulin signaling through mammalian target of rapamycin (mTOR). Whether SNAT2 also regulates signaling to pathways that control proteolysis is unknown. In this study, inhibition of SNAT2 with the selective competitive substrate methylaminoisobutyrate or metabolic acidosis (pH 7.1) depleted intracellular L-Gln and stimulated...
Source: Drug Law Weekly (2008-12-16)
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