Drug Development
New research on drug development from Endocyte, Inc. summarized
Published in Drug Law Weekly, January 13th, 2009
According to a study from the United States, "Herein, we present a detailed analysis on the effects of feeding laboratory mice both high and low folic acid (folate)-containing diets as related to associated changes in serum and red blood cell (RBC) folate levels, tissue-derived folate receptor levels, and the ability of folate-drug conjugates to bind and effectuate activity against folate receptor (FR)-positive tumor xenografts. Our data show that serum and RBC folate concentrations sharply drop immediately after mice are switched to low folate diets; however, both parameters reach steady-state, ''humanlike'' levels after 6 weeks."
"Interestingly, tissue-related folate...
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Source: Drug Law Weekly (2009-01-13)
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