Alzheimer Disease

Scientists at University of Pennsylvania publish new data on Alzheimer disease

Published in Drug Law Weekly, January 13th, 2009

"Tumor necrosis factor-alpha(TNF alpha) is a proinflammatory cytokine that is elevated in Alzheimer's disease (AD) brains. Because TNF alpha is released from cell membranes by the TNF alpha-converting enzyme (TACE), inhibition of TACE has the potential to mitigate TNF alpha effects in AD brain," scientists in the United States report.

"TACE also cleaves amyloid precursor protein (APP) and generates sAPP alpha, precluding the formation of potentially harmful amyloid beta (A beta) peptides by beta-site APP cleaving enzymes (BACE). Hence, the anti-inflammatory benefits of TACE inhibition might be offset by an increase in A beta. We have examined the effects of the highly...

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Source: Drug Law Weekly (2009-01-13)

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