Published in Drug Law Weekly, January 13th, 2009
"TACE also cleaves amyloid precursor protein (APP) and generates sAPP alpha, precluding the formation of potentially harmful amyloid beta (A beta) peptides by beta-site APP cleaving enzymes (BACE). Hence, the anti-inflammatory benefits of TACE inhibition might be offset by an increase in A beta. We have examined the effects of the highly...
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