Pancreatic Cancer

Research findings from B.M. Wolpin et al update understanding of pancreatic cancer

Published in Drug Law Weekly, February 24th, 2009

According to recent research from the United States, " The PI3K/Akt/mTOR pathway is activated in the majority of pancreatic cancers, and inhibition of this pathway has antitumor effects in preclinical studies. We performed a multi-institutional, single-arm, phase II study of RAD001(everolimus), an oral inhibitor of mTOR, in patients who experienced treatment failure on first-line therapy with gemcitabine."

"Patients and Methods Thirty-three patients with gemcitabine-refractory, metastatic pancreatic cancer were treated continuously with RAD001 at 10 mg daily. Prior treatment with fluorouracil in the perioperative setting was allowed. Patients were observed for toxicity,...

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Source: Drug Law Weekly (2009-02-24)

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