Lung Cancer

Research from Aarhus University has provided new information about lung cancer

Published in Drug Law Weekly, March 24th, 2009

"Erlotinib (Tarceva) targets the epidermal growth factor receptor (EGFR), which is commonly overexpressed in human cancers, including lung cancer. We show that erlotinib can be labeled with [C-11] by reacting the normethyl precursor with [C-11]-methyl iodide," researchers in Aarhus, Denmark report.

"By using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide proliferation assay, two lung cancer cell lines (A549 and NCI358) were shown to be less sensitive to erlotinib compared with the lung cancer cell line HCC827. This correlated with higher expression and activity of the EGFR in HCC827 cells as compared with the less sensitive cell lines. Micro-positron...

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Source: Drug Law Weekly (2009-03-24)

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