Life Sciences
Researchers at Yale University, Medical Department target life sciences
Published in Drug Law Weekly, March 31st, 2009
According to a study from the United States, "Understanding mechanisms controlling expression of the alpha-spectrin gene is important for understanding erythropoiesis, membrane biogenesis, and spectrin-linked hemolytic anemia. We showed previously that a minimal alpha-spectrin promoter directed low levels of expression only in early erythroid development, indicating elements outside the promoter are required for expression in adult erythrocytes."
"Addition of noncoding exon 1' and intron 1' conferred a 10-fold increase in activity in reporter gene assays. In this report, we used a transgenic mouse model to show that addition of exon 1' and intron 1' to the...
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Source: Drug Law Weekly (2009-03-31)
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