Hormones

Studies from University of Minnesota further understanding of hormones

Published in Drug Law Weekly, April 21st, 2009

"Previous research indicates that progesterone (PROG) decreased cocaine-seeking behavior in female rats. This effect of PROG may be in part due to its metabolite allopregnanolone (ALLO), which has been shown to decrease the sensitizing effects of cocaine and reduce lethality associated with cocaine overdose in mice," scientists writing in the journal Psychopharmacology report.

"The purpose of the present study was to examine the effects of ALLO on the reinstatement of cocaine-seeking behavior in female and male rats. Rats were trained to lever press for i.v. infusions of cocaine (0.4 mg/kg per infusion) during 2-h sessions, and once acquisition criteria were met,...

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Source: Drug Law Weekly (2009-04-21)

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