Tuberculosis
Research from University of Oxford in tuberculosis provides new insights
Published in Drug Law Weekly, May 12th, 2009
"Although host genetics influences susceptibility to tuberculosis (TB), few genes determining disease outcome have been identified. We hypothesized that macrophages from individuals with different clinical manifestations of Mycobacterium tuberculosis (Mtb) infection would have distinct gene expression profiles and that polymorphisms in these genes may also be associated with susceptibility to TB," scientists in Vietnam report.
"We measured gene expression levels of > 38,500 genes from ex vivo Mtb-stimulated macrophages in 12 subjects with 3 clinical phenotypes: latent, pulmonary, and meningeal TB (n=4 per group). After identifying differentially expressed genes, we...
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Source: Drug Law Weekly (2009-05-12)
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