Gastroenterology

Research conducted at University of Manchester has provided new information about gastroenterology

Published in Drug Law Weekly, June 9th, 2009

"To assess the extent of intestinal and hepatic glucuronidation in vitro and resulting implications on glucuronidation clearance prediction. Alamethicin activated human intestinal (HIM) and hepatic (HLM) microsomes were used to obtain intrinsic glucuronidation clearance (CLint,UGT) for nine drugs using substrate depletion," investigators in Manchester, the United Kingdom report.

"The in vitro extent of glucuronidation (fm(UGT)) was determined using P450 and UGT cofactors. Utility of hepatic CLint for the prediction of in vivo clearance was assessed. fm(UGT) (8-100%) was comparable between HLM and HIM with the exception of troglitazone, where a nine-fold difference was...

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Source: Drug Law Weekly (2009-06-09)

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