Enzyme Research

Researchers from University of California detail findings in enzyme research

Published in Drug Law Weekly, August 11th, 2009

"The branched-chain amino acids (BCAA) are essential amino acids required for protein homeostasis, energy balance, and nutrient signaling. In individuals with deficiencies in BCAA, these amino acids can be preserved through inhibition of the branched-chain-alpha-ketoacid dehydrogenase (BCKD) complex, the rate-limiting step in their metabolism," investigators in the United States report.

"BCKD is inhibited by phosphorylation of its E1 alpha subunit at Ser293, which is catalyzed by BCKD kinase. During BCAA excess, phosphorylated Ser293 (pSer293) becomes dephosphorylated through the concerted inhibition of BCKD kinase and the activity of an unknown intramitochondrial...

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Source: Drug Law Weekly (2009-08-11)

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