Chromatography

Data from AstraZeneca advance knowledge in chromatography

Published in Drug Law Weekly, August 25th, 2009

According to recent research from Macclesfield, the United Kingdom, "A comparison is made of the separation and analysis of a test probe, AZD5438 (4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)-N-[4-(methylsulfonyl)phenyl]pyrimidin-2-amine), and its metabolites using conventional LC, UPLC and high temperature liquid chromatography (HTLC)."

"LC and UPLC separations were performed using reversed-phase water:acetonitrile solvent systems whilst HTLC was performed with an entirely aqueous mobile phase, using both isothermal and temperature gradient chromatography. Substantial reductions in run times were observed with both UPLC and HTLC compared to the conventional LC approach...

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Source: Drug Law Weekly (2009-08-25)

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