Fibrosis

Data on fibrosis detailed by H. Pietsch and co-authors

Published in Drug Law Weekly, September 22nd, 2009

In this recent study, researchers in Berlin, Germany conducted a study "To investigate the possible role of Zn as a trigger for NSF we were using a previously established preclinical model. The depletion of endogenous Zinc ions (Zn) caused by the administration of gadolinium-based contrast agents (GBCAs) has been suggested as a possible pathomechanism for nephrogenic systemic fibrosis (NSF)."

"In the Zn supplementation study, rats were injected with Gadodiamide, Omniscan, and Magnevist with or without Zn supplementation. In the Zn depletion study, animals were kept on a Zn-deficient diet or a special control diet and received injections of Omniscan, OptiMARK,...

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Source: Drug Law Weekly (2009-09-22)

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