Pancreas
New pancreas findings from Ohio State University published
Published in Drug Law Weekly, October 6th, 2009
"Previous studies using knockout mice document a key role for the integrin CD103 in promoting organ allograft rejection and graft-versus-host disease. However, a determination of whether blockade of the CD103 pathway represents a viable therapeutic strategy for intervention in these processes has proven problematic due to the lack of reagents that efficiently deplete CD103(+) cells from wild type hosts," scientists writing in the American Journal of Transplantation report.
"To circumvent this problem, we conjugated the nondepleting anti-CD103 monoclonal antibody, M290, to the toxin, saporin, to produce an immunotoxin (M290-SAP) that efficiently depletes CD103(+)...
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Source: Drug Law Weekly (2009-10-06)
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