Stomatitis

Scientists at McMaster University target stomatitis

Published in Drug Law Weekly, October 13th, 2009

According to recent research from Hamilton, Canada, "Dendritic cell (DC)-based vaccines are a promising -strategy for tumor immunotherapy due to their ability to activate both antigen-specific T-cell immunity and innate immune effector components, including natural killer (NK) cells. However, the optimal mode of antigen delivery and DC activation remains to be determined."

"Using M protein mutant vesicular stomatitis virus(Delta M51-VSV) as a gene-delivery vector, we demonstrate that a high level of transgene expression could be achieved in similar to 70% of DCs without affecting cell viability. Furthermore, Delta M51-DCs infection activated DCs to produce...

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Source: Drug Law Weekly (2009-10-13)

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