Acute Myeloid Leukemia

Findings from INSERM broaden understanding of acute myeloid leukemia

Published in Drug Law Weekly, October 13th, 2009

According to recent research from Paris, France, "The deregulation of translation markedly contributes to the malignant phenotype in cancers, and the assembly of the translation initiating complex eIF4F is the limiting step of this process. The mammalian Target of Rapamycin Complex 1 (mTORC1) is thought to positively regulate eIF4F assembly and subsequent oncogenic protein synthesis through 4E-BP1 phosphorylation."

"We showed here that the translation inhibitor 4EGI-1 decreased the clonogenic growth of leukemic progenitors and induced apoptosis of blast cells, with limited toxicity against normal hematopoiesis, which emphasize the importance of translation deregulation...

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Source: Drug Law Weekly (2009-10-13)

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