Non-Small Cell Lung Cancer

Research from University of California in the area of non-small cell lung cancer published

Published in Drug Law Weekly, January 12th, 2010

According to recent research from the United States, "Activating mutations in the epidermal growth factor receptor (EGFR) are associated with enhanced response to EGFR tyrosine kinase inhibitors in non-small cell lung cancer (NSCLC), whereas KRAS mutations translate into poor patient outcomes. We hypothesized that analysis of plasma for EGFR and KRAS mutations from shed tumor DNA would have clinical utility."

"An allele-specific polymerase chain reaction assay using Scorpion-amplification refractory mutation system (DxS, Ltd) was used to detect mutations in plasma DNA from patients with advanced stage NSCLC treated as second- or third-line therapy on a phase I/II trial...

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Source: Drug Law Weekly (2010-01-12)

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