Salmonellosis Therapy

Researchers at Center for Cancer Research release new data on salmonellosis therapy

Published in Drug Law Weekly, January 19th, 2010

Scientists discuss in 'A PhoQ/P-regulated small RNA regulates sensitivity of Escherichia coli to antimicrobial peptides' new findings in salmonellosis. "Non-coding small RNAs (sRNAs) play a major role in post-transcriptional regulation of gene expression. Of the 80 sRNAs that have been identified in E. coli, one-third bind to the RNA chaperone Hfq," investigators in the United States report.

"Hfq both stabilizes these sRNAs in vivo and stimulates pairing to targets in vitro. A novel Hfq-dependent RNA, called here MgrR, was identified by its ability to bind Hfq. Expression of MgrR requires the PhoQ/PhoP two-component system; the PhoP response regulator is active...

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Source: Drug Law Weekly (2010-01-19)

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