Dopamine Therapy

Reports from H.D. Wang and co-researchers add new data to research in dopamine therapy

Published in Drug Law Weekly, January 19th, 2010

According to a study from the United States, "Recent data indicate that cortical dopamine denervation results in dystrophic changes in the dendrites of pyramidal cells, including decreases in dendritic spine density and length. However, it is not known if the loss of signaling through specific dopamine receptors subserves these dendritic changes."

"We examined the dendritic structure of layer V pyramidal cells in the prefrontal cortex of D-1, D-2, and D-4 dopamine receptor null mutant mice and their wild-type littermates. Decreased basal dendritic length and spine density were observed in the D-1 knockout mice. Similarly, a decrease in basal dendritic spine density was...

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Source: Drug Law Weekly (2010-01-19)

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